Concept program of the Second joined meeting of DEBS and MiVab

Date: November 15th and 16th 2012

Location: Biezenmortel

Organizers: DEBS & MIVAB

Thursday, November 15

12.30 – 13.00 Welcome and opening + small lunch + drinks

13.00 – 14.00 NHS Keynote lecture Dr. Chris Carman (Harvard, US)

"Homeostatic and Recuperative Cytoskeletal Remodeling Dynamics in Endothelium"

14.00 – 15.30 Vascular Barrier Function session

Janine van Gils (LUMC, Leiden)

The RNA-binding protein Quaking maintains endothelial barrier function through targeting VE-cadherin mRNA

Ilse Timmerman (Sanquin, Amsterdam)

The GEF Trio is crucial for the formation of VE-cadherin-mediated cell-cell junctions through the activation of Rac1

Joppe Oldenburg (Hubrecht Institute, Utrecht)

Force dependent localization of VASP and Zyxin at Cadherin junctions is independent of Vinculin

Mark Mizee (VUMC, Amsterdam)

Retinoic acid in MS: its protective role at the neurovascular unit

15.30 – 16.00 Break

16.00 – 17.30 Vasculature in Health and Disease session

Hanke Matlung (Sanquin, Amsterdam)

Regulation of phagocyte migration by SIRPα signaling

Mathijs Ruiter (AMC, Amsterdam)

Safer drug-eluting stents inhibit restenosis and promote re-endothelialization

Monique van Lier (AMC, Amsterdam)

Coronary flow distribution and vascular adaptation in a rabbit ischemia model

Martijn Dane (LUMC, Leiden)

Loss of endothelial surface glycocalyx in the glomerular filtration barrier as a first step towards development of proteinuria.

18.00 – 19.00 Diner

19.15 – 20.00 “Endothelial Dysfunction” debate between Prof. Victor van Hinsbergh (VU, Amsterdam) and Prof. Coen Stehouwer (MUMC, Maastricht)

20.00 – late Poster session with drinks

Friday, November 16

8.00 – 9.00 Breakfast

9.00 – 10.30 Vascular Signaling session

Ed Eringa (VUMC, Amsterdam)

IRS1 deficiency reduces muscle perfusion, resistance artery diameter and vascular insulin signaling in mice.

Bilge Guvenc Tuna (AMC, Amsterdam)

Intrinsic balance of small artery active and passive diameter-tension relations

Rick Meijer (VUMC, Amsterdam)

AMPKα2 regulates insulin-induced microvascular recruitment through critical control over Ser1177 phosphorylation of eNOS

Antje Schaefer (Sanquin, Amsterdam)

The force from within – how endothelial actin-binding proteins control leukocyte transmigration

10.30 – 11.00 Break

11.00 – 12.00 Keynote Prof. Peter Hordijk (Sanquin, Amsterdam)

“The hypervariable end of Rac1: a tail of many stories”

12.00 – 13.00 Lunch

13.00 – 14.30 Angiogenesis and Vascular Remodelling session

Dennie Tempel (Erasmus UMC, Rotterdam)

PLVAP promotes angiogenesis by stimulating the endothelial production of pro-angiogenic S1P

Robert Szulcek (VUMC, Amsterdam)

Characterization of lung microvascular endothelium from pulmonary arterial hypertension patients under high shear stress

Javier Martin-Ramirez (Sanquin, Amsterdam)

Decreased propagation of blood outgrowth endothelial cell colonies in subjects with advanced subclinical atherosclerosis

Bas van Balkom (UMC, Utrecht)

Suppression of senescence by exosome-mediated transfer of miR-214 allows induction of an angiogenic program in human and mouse endothelial cells

14.30 – 15.00 Break

15.00 – 16.00 Keynote Prof. Grietje Molema (UMCG, Groningen)

“Targeted drug delivery as a tool to serve in vivo endothelial biology”