On February 4th and 5th 2010, the joined meeting of the DEBS and the MiVaB was organized at the conference center “De Beukenhof” in Biezenmortel, NL.


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Program MIVAB/DEBS congress February 4th and 5th 2010 at the Beukenhof, Biezenmortel.

Day 1:

10.00: Opening (Bibliotheek)

10.30 – 11.30 Keynote Netherlands Heart Foundation Lecture

Prof. Dr. Paul Kubes, University of Calgary, Alberta, Canada

The Key Role of Endothelium in Intravascular Immunity

11.30 – 11.45 Hetty de Boer, Leiden University Medical Center

CD34+/KDR+ cells are generated from CD34+ cells under flow after immobilization on activated platelets and may serve as a marker for vascular injury

11.45 – 12.00 Timo Rademakers, Maastricht University Medical Center

Two-Photon Microscopic Imaging of Plaque-Associated Neo-Vasculature in Mice

12.00 – 12.15 Geerten van Nieuw Amerongen, VU Medical Center Amsterdam

Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces,

12.30- 13.30 Lunch

13.30 – 14.45 Parallel session I (Bibliotheek)

Endothelial cell biology

13.30 - 13.45 Karine M. Valentijn, Leiden University Medical Center Imaging von Willebrand Factor in and out of endothelial cells

13.45 - 14.00 Jack A. Valentijn, Leiden University Medical Center Multigranular exocytosis of Weibel-Palade bodies in vascular endothelial cells

14.00 - 14.15 Jiong-Wei Wang, Leiden University Medical Center

Effects of von Willebrand factor mutations on the formation, structure and regulated secretion of Weibel-Palade bodies

14.15 - 14.30 Ilse Botden, Erasmus Medical Center Rotterdam

Do red wine extracts improve endothelial function and cholesterol metabolisma via SIRT1?

14.30 - 14.45 Mark Mizee, VU Medical Center Amsterdam

Differentiation of brain endothelial cells

13.30 – 14.30 Parallel session II (Bibliotheek ‘Hemel’)

Translational studies

13.30 - 13.45 Stephen Arends, Maastricht University Medical Center

Functional heterogeneity of IgG anti-endothelial cell antibodies in pulmonary arterial hypertension

13.45 - 14.00 Nienke J. Wijnstok, VU Medical Center Amsterdam

Relationship between obesity and microvascular function: The Amsterdam Growth and Health Longitudinal Study

14.00 - 14.15 Cristina Rolandi, Academic Medical Center Amsterdam

Effect of the valsalva maneuver on cardiac-coronary interaction studied by coronary wave intensity in humans

14.15 - 14.30 Mieke van den Heuvel, Erasmus Medical Center Rotterdam

Identification of patients at risk of coronary artery disease by assessment of digital reactive hyperemia in a clinical outpatient setting

14.45 – 15.15 Coffee break

15.15 - 17.15 Parallel session I (Bibliotheek)

Vascular tension I

15.15 - 15.30 Vincent de Beer, Erasmus Medical Center Rotterdam Endothelial Control of Coronary Vascular Tone is Altered After MI: Interactions of Nitric Oxide and Prostanoids with Endothelin

15.30 - 15.45  Elza van Deel, Erasmus Medical Center Rotterdam

eNOS overexpression fails to protect against pressure overload induced cardiac hypertrophy and dysfunction by elevating levels of reactive oxygen species

15.45 - 16.00 Rick Meijer, VU Medical Center Amsterdam

Vasodilator effects of perivascular adipose tissue by AMPK activation are blunted in obesity

16.00 - 16.15 Jaqueline Hornstra, VU Medical Center Amsterdam

Folic acid and 5-methyltetrahydrofolate equally improve vascular reactivity of homocysteine-exposed rat muscle resistance arteries.

16.15 - 16.30 Short break

Vascular tension II

16.30 - 16.45 Marieke Schoorl, Academic Medical Center Amsterdam

Endothelin-1 induces smooth muscle cell plasticity in small mesenteric arteries

16.45 - 17.00 Jeroen van den Akker, Academic Medical Center Amsterdam

Redox balance controls transglutaminase activity in microvascular remodeling

17.00 – 17.15 Lonneke Link, Maastricht University Medical Center

Effects of a physiological hyperinsulinaemia on the microcirculation

15.15 - 17.30 Parallel session II (Bibliotheek ‘Hemel’)

Inflammation I

15.15 - 15.30 Gopala Yakala, University Medical Center Groningen

The effect of continuous and alternate high-cholesterol feeding on endothelial activation in the kidney

15.30 - 15.45  David Engel, Maastricht University Medical Center

Protection against atherosclerosis in CAV-1-/-mice is due to CAV-1-/- in non-hematopoietic cells

15.45 - 16.00 Cancu Yildirim, VU Medical Center Amsterdam

Immune modulation by KLF2 to improve collateral artery development

16.00 - 16.15 Neng Fisheri Kurniati, University Medical Center Groningen Endothelial Heterogeneity of Tie2 and GATA3 Expression in Response to Pro-inflammatory Stimuli

16.15 - 16.30 Break


16.30 - 16.45 Ingeborg Klaassen, Academic Medical Center Amsterdam

Differential TGF-β signaling in retinal vascular cells: a role in diabetic retinopathy?

16.45 - 17.00 Micha Nethe, Sanquin Research

Caveolin-1 regulates ubiquitination of Rac1

17.00 - 17.15 Ilse Timmerman, Sanquin Research

Regulation of the endothelial barrier function by

tyrosine phosphorylation of VE-cadherin

17.15 - 17.30 Thomas Leyen, VU Medical Center Amsterdam

Specific actin ‘shear fibre’ structures are present in various types of endothelium exposed to shear stress or overexpressing KLF2

17.30 – 18.15 Jaarvergadering MiVaB (Bibliotheek)

18.15 – 19.15 Diner

19.15 – 21.15 Poster session

  1. Felix F. Kolk: Early prediction of collagen production in vascular tissue engineering.
  2. Asim Mohammed: A role for Annexin A2 in regulating transendothelial migration of leukocytes.
  3. Floris van Alphen: Different flow-models to study shear stress-mediated morphological changes in endothelial cells.
  4. Emilie Reinen: Cellular Prion Protein (PrPc) in Hematopoietic and Endothelial Cells.
  5. Dorothee van Breevoort: Proteomics of Weibel-Palade bodies; endothelial cell-specific storage organelles crucial for maintaining vascular homeostasis.
  6. Hanke Matlung: Transglutaminases locate to calcified areas in human atherosclerotic lesions.
  7. Dennis Muris: The role of microvascular dysfunction in the pathogenesis of type 2 diabetes and diabetes-related complications: the Maastricht Study.
  8. Bianca Groenendijk: Increasing the retention of progenitor cells in infarcted myocardium.

Day 2:

09.00 – 10.00  Keynote Netherlands Heart Foundation Lecture (Bibliotheek)

Prof. Dr. Helmut Augustin, Medical Faculty Mannheim, Heidelberg University, and German Cancer Research Center Heidelberg, Germany.

The vascular endothelium – an underappreciated systemically disseminated organ

10.00 – 10.30 Coffee break

10.30 – 11.30 Parallel session I (Bibliotheek ‘Hemel’)

Inflammation II

10.30 - 10.45 Francis Wulfert, University Medical Center Groningen

Increased renal microvascular endothelial responsiveness to LPS in aged mice

10.45 - 11.00 Nuray Gul, VU Medical Center Amsterdam.

Surgery-induced inflammation stimulates liver metastasis development by disrupting vascular lining

11.00 – 11.15 Bart Eskens, Maastricht University Medical Center

Loss of glycocalyx barrier properties impairs insulin-

mediated recruitment of microvascular blood volume in rat hind limb muscle.

11.15 – 11.30  Dan Potter, Maastricht University Medical Center

The recovery time course of the endothelial cell

glycocalyx in vivo and its implications in vitro

10.30 – 11.15 Parallel session II

Angiogenesis (Bibliotheek)

10.30 – 10.45 Gesiena Elise van der Wal, University Medical Center Groningen

Angiogenesis in synchronous and metachronous hepatic metastasis of colorectal cancer. The liver as a permissive soil

10.45 – 11.00 Elise Langenkamp, University Medical Center Groningen Pharmacological inhibition of VEGFR2 results in a loss of VEGFR2 protein and a shift in tumor endothelial gene expression towards vascular stabilization

11.00 – 11.15 Stephan Huveneers, Hubrecht Institute Utrecht

Regulation of the VE-cadherin complex by angiogenic signals

11.30 – 12.30 Keynote lecture (Bibliotheek)

Dr. Esther Lutgens, Maastricht University Medical Center, The Netherlands.

Deficient CD40-TRAF6 signaling in leukocytes prevents atheroscelrosis by skewing the immune resposne towards an anti-inflammatory profile.

12.30 – 13.30 Presentation price winners Oral Presentation (2) and Poster presentation, followed by Lunch.


pseudo-colored human umbilical vein endothelial cell.



Many topics of endothelial cell biology research were discussed during oral and poster presentations.

Dr. Paul Kubes, Dr. Helmut Augustin and Dr. Esther Lutgens gave outstanding keynote lectures.

We hope to see you back at one of our future meetings!!!

The meeting was supported by

the Dutch Heart Foundation,


Ibidi GmbH,

Greiner Bio-One B.V.