Program Netherlands Vascular Biology Meeting 2016; Biezenmortel

Wednesday, October 5th Location: Bibliotheca

12.30 – 13.30     Welcome and opening + small lunch buffet + coffee/tea.

13:30 – 14:00     NHS Keynote EC biology Prof. Dr. Lars Holmgren (Stockholm, Sweden):Amot proteins: integration of mechanical force in development”.

14:00 - 14:15 The F-BAR protein pascin2 regulates asymmetric VE-cadherin internalization from tensile adherens junctions; Tsveta Malinova, AMC, Amsterdam.

14.15 – 14.30 The RhoGEF Trio controls endothelial cell-cell junction stability through Rap1 activation; Jos van Rijssel, Sanquin research, Amsterdam.

14:30 – 14:45 Sphingosine-1-phosphate-mediated endothelial barrier regulation: balancing G-protein and RhoGTPase signaling; Nathalie Reinhard, Swammerdam Institute for Life Sciences, Amsterdam.

14:45 – 15:00 The neuronal guidance cue semaphorin 3F is highly expressed by endothelial cells upon laminar flow and is important for endothelial barrier function; H. Zhang, LUMC, Leiden.

15:15 – 15.45     Break - Coffee/tea

15.45 – 16.15 Keynote Clinical microcirculation Dr. Ylva Hellsten: “Microvascular dysfunction in lifestyle related disease- mechanisms and consequences”.

16.15 – 16.30 Vasculotide, a Tie2 agonist, restores microcirculatory perfusion during fluid resuscitation and reduces microvascular leakage during hemorrhagic shock; C.E. van de Brom, VUMC, Amsterdam.

16:30– 16:45 Correlation of carotid artery reactivity with cardiovascular risk factors and coronary artery vasodilator responses in asymptomatic, healthy volunteers; Anke C.C.M van Mil, Radboud, Nijmegen.


17:00 – 17:30     Refreshments

17:30 – 18:30    Debate on “Research publication and integrity”

· Chris Hartgerink from University of Tilburg: “How to judge your own data

· Prof. Dr. Peter L. Hordijk  from VUMC: “Detecting scientific fraud: and now what?”

18.30 – 19.30     Diner (Restaurant)

19:30 – 20:30    GUIDE Keynote Prof. Dr. Teresa Sanchez (Assistant Professor of Pathology and Laboratory Medicine, Principal Investigator, Microvascular Injury Laboratory, Weill Cornell Medicine, New York, NY.):Sphingolipid Signaling in Acute Neurovascular Injury”

> 20:30 Poster session with drinks

Location: Feestzaal

Thursday, October 6th Location: Bibliotheca

8.00 – 9.00         Breakfast (Restaurant)


9.00 – 9.30         Keynote Heinz-Georg Belting (Basel, Switserland):An actin/VE-cadherin-based ratchet mechanism drives endothelial cell rearrangements in vivo”.

9:30 – 9:45 PLVAP regulates angiogenesis through VEGFR2, I. Klaassen, AMC, Amsterdam.

9:45– 10:00 LIM-only Protein FHL2 Suppresses Pulmonary Artery Endothelial Cell Proliferation through Activation of BMP Signalling; Kondababu Kurakula, LUMC, Leiden.

10:00– 10:15 Divergent and convergent PAR1,2,3,4 and histamine-induced signal transduction pathways in endothelial cells uncovered by quantitative phosphoproteomics; Bart van den Eshof, Sanquin research, Amsterdam.

10:15 – 10:30 Macrophage-specific reduction of glycolysis changes circulating immune cell expression but does not affect atherogenesis; Bianca Sander, MUMC, Maastricht

10.30 – 11.00     Break- Coffee/tea

11.00 – 11.30    Keynote Vascular pathologies Dr. Jason Johnson (Bristol, UK): Narrowing Down the Culprit MMPs in Atherosclerotic Plaque Progressiones”

11:30– 11:45 Perivascular Adipose Tissue Controls Insulin-induced Vasodilatation and Muscle Perfusion in vivo; Alexander H Turaihi, VUMC, Amsterdam.

11:45– 12:00 Rutin protects against endothelial dysfunction and induces Nrf2-mediated adaptation in HUVECs exposed to oxidative stress; Mireille M.J.P.E. Sthijns, CARIM, Maastricht.

12:00– 12:15 Fibroblast as the overlooked player in atherosclerosis?; Kim van Kuijk, CARIM, Maastricht.

12:15– 12:30 Organ-specific endothelial responses to LPS in a novel heterozygous Tie2 knockout mouse model; Rianne M. Jongman, UMCG, Groningen.

12.30 – 13.30     Lunch

13.30 –14.30 NHS Keynote EC metabolism: Dr. Guy Eelen (Carmeliet lab, Leuven, Belgium): “Angiogenesis revisited: role and (therapeutic) implications of endothelial metabolism”.

14:30    Prize winners for Oral / Poster

15:00    End of meeting